大連醫(yī)科大學(xué)秘曉林教授課題組招收2020年碩士研究生

　　一、課題組介紹

　　秘曉林，博士，教授，博士研究生導(dǎo)師。入選中國科學(xué)院“引進(jìn)國外杰出人才--百人計(jì)劃”，遼寧省“攀登學(xué)者”。國家重大科學(xué)研究計(jì)劃、國家自然科學(xué)基金、博士后科學(xué)基金、美國國家科學(xué)基金研究生項(xiàng)目等評議人，SCI雜志International Journal of Nanomedicine顧問編委，PLoS ONE、Current Proteomics編委，中國生化藥物雜志編委，中國環(huán)境誘變劑學(xué)會理事，遼寧省醫(yī)學(xué)會醫(yī)學(xué)遺傳學(xué)分會副主任委員，Biomaterials、Genetics、International Journal of Nanomedicine等SCI雜志審稿人。主持國家重點(diǎn)基礎(chǔ)研究計(jì)劃“973”課題、國家自然科學(xué)基金項(xiàng)目、中國科學(xué)院創(chuàng)新項(xiàng)目等。

　　1990年畢業(yè)于蘭州大學(xué)生物化學(xué)專業(yè)，獲理學(xué)學(xué)士學(xué)位;1996年畢業(yè)于衛(wèi)生部蘭州生物制品研究所免疫學(xué)和微生物學(xué)專業(yè)，獲碩士學(xué)位;1999年畢業(yè)于中國預(yù)防醫(yī)學(xué)科學(xué)院病毒學(xué)研究所病原生物學(xué)專業(yè)，獲博士學(xué)位。同年赴美國，在國立衛(wèi)生研究院(National Institutes of Health)國家癌癥研究所(National Cancer Institute)從事博士后研究，隨后任職美國國立衛(wèi)生研究院國家癌癥研究所研究學(xué)者。作為通訊作者，研究成果發(fā)表在Proceedings of National Academy of Sciences USA, Oncogene, Biomaterials, Human Molecular Genetics, Journal of Cell Science等國際知名學(xué)術(shù)期刊。

　　研究方向

　　1. 非編碼RNA(miRNA和lncRNA)應(yīng)答DNA損傷，調(diào)節(jié)細(xì)胞周期、凋亡、轉(zhuǎn)錄的功能和機(jī)制;

　　2. 腸道干細(xì)胞再生與分化的表觀遺傳調(diào)控。

　　代表性文章(*通訊作者)

　　1. Li D., Liu Y., Pei C., Zhang P., Pan L., Xiao J., Meng S., Yuan Z., Bi X. * miR-285-Yki/Mask double-negative feedback loop mediates blood-brain barrier integrity in Drosophila. Proceedings of National Academy of Sciences USA. 2017. 114(12): E2365-E2374. IF 9.7

　　2. Song F., Li D., Wang Y., Bi X.* Drosophila Caliban mediates G1-S transition and ionizing radiation induced S phase checkpoint. Cell Cycle. 2018. 17(18): 2256-2267. IF 3.3

　　3. Yuan Q., Tian R., Zhao H., Li L., Bi X. * Multiple arginine residues are methylated in Drosophila Mre11 and required for survival following ionizing radiation. G3: Genes Genomes Genetics. 2018. 8 (6): 2099-2106. IF 2.7

　　4. Li D. and Bi X. * Effect of Teratogens on Development of Drosophila melanogaster. Teratogenicity Testing: Methods and Protocols. Methods in Molecular Biology. Springer. 2018. 1797:233-241.

　　5. Cong, W., Wang, P., Qu, Y., Tang, J., Bai, R., Zhao, Y., Chen, C., Bi, X. * Evalutation of the influence of Fullerenol on aging and stress resistance using Caenorhabditis elegans. Biomaterials. 2015. 42:78-86. IF 8.6

　　6. Jiang K., Liu M., Lin G., Mao B., Cheng W., Liu H., Gal J., Zhu H., Yuan Z., Deng W., Liu Q., Gong P., Bi X. *, Meng S. * Tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death. Oncotarget. 2016. 7 (18): 25652-25667. IF 5.2

　　7. Qian X., Wang P., Xia Y., Dou T., Jin Q., Wang D., Hao D., Bi X. *, Ge G. *, Yang L. * A highly selective fluorescent probe for sensing activities of catechol-O-methyltransferase in complex biological samples. Sensors and Actuators B. 2016. 231:615–623. IF 5.4

　　8. Chen, H., Wang, B., Feng, W., Du, W., Ouyang, H., Chai, Z., Bi, X.* Oral Magnetite Nanoparticles Disturb the Development of Drosophila Melanogaster from Oogenesis to Adult Emergence. Nanotoxicology. 2015. 9(3):302-312. IF 7.9

　　9. Yuan, Q., Han, J., Cong, W., Ge, Y., Ma, D., Dai, Z., Li, Y., Bi, X. * Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with improved cell apoptosis and gene expression profile and reduced myelosuppression toxicity. International Journal of Nanomedicine. 2014. 9(1): 4829-4846. IF 4.3

　　10. Fang, G., Zhang, D., Yin, H., Zheng, L., Bi, X.*, Yuan, L.* Centlein maintains centrosome cohesion by bridging an interaction between C-Nap1 and Cep68. Journal of Cell Science. 2014. 127 :1631-1639. IF 5.4

　　11. Wang, Y., Wang, Z., Joshi, BH., Puri, R., Stultz, B., Yuan, Q., Bai, Y., Zhou, P., Yuan, Z., Hursh, DA., Bi, X.* The tumor suppressor Caliban regulates DNA damage induced apoptosis through p53-dependent and –independent activity. Oncogene. 2013. 32(33):3857-66. IF 8.6

　　12. Liu, W., Jiang, F., Bi, X.*, Zhang, Q*. Drosophila FMRP participates in DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis. Human Molecular Genetics. 2012, 21(21):4655-68. IF 7.7

　　13. Kong, L., Yuan Y., Zhu, H., Li, Y., Guo, Q., Zhao, Y., Wang, Q., Bi, X.*, Gao,X*. The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis. Biomaterials. 2011.32(27)：6515-6522. IF 7.6

　　14. Wang, P., Bai, Y., Song, B., Wang, Y., Liu, D., Lai, Y., Bi, X.*, Yuan, Z*. PP1A-mediated dephosphorylation positively regulates YAP2 activity. PLoS ONE. 2011.6(9):e24288. IF 4.1

　　15. Gao, G., Bi, X., Chen, J., Srikanta, D., Rong, YS. Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis. Proceedings of National Academy of Sciences USA. 2009. 106(26): 10728–10733.(Equal contribution). IF 9.4

　　16. Bi, X., Jones, T., Abbasi, F., Lee, H., Stultz, B., Hursh, D., Mortin, M. Drosophila Caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. Oncogene. 2005. 24:8229-8239. IF 6.8

　　17. Bi, X., Srikanta, D., Fanti,L., Pimpinelli,S., Badugu,R., Kellum,R., Rong, Y.S. Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. Proceedings of National Academy of Sciences USA. 2005. 102(42):15167-15172. IF 10.2

　　18. Bi, X., Gong, M., Srikanta, D., Rong, Y.S. Drophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation. Genetics. 2005. 171:845-847. IF 4.4

　　19. Bi, X., Wei, S.D., Rong, Y.S. Telomere protection without a telomerase: the role of ATM and Mre11 in Drosophila telomere maintenance. Current Biology. 2004. 14:1348-1353. IF 11.9

　　20. Bi, X., Kajava, A., Demidenko, Z., Jones, T., Mortin, M. The carboxyl terminus of Prospero regulates its subcellular localization. Molecular and Cellular Biology. 2003. 23 (3): 1014-1024. IF 8.9

　　二、招收條件和招生專業(yè)

　　符合我校2020年攻讀碩士學(xué)位研究生招生簡章要求，初試成績達(dá)到全國一類地區(qū)碩士研究生初試分?jǐn)?shù)線的普通全日制本科考生。要求生命科學(xué)背景，對科研有濃厚興趣，勤于思考，能夠閱讀英語專業(yè)文獻(xiàn)，具備團(tuán)隊(duì)精神。

　　招生院系：基礎(chǔ)醫(yī)學(xué)院。

　　招生專業(yè)：細(xì)胞生物學(xué)。

　　有攻讀博士意向的考生優(yōu)先考慮。

　　三、聯(lián)系方式

　　有意到我課題組攻讀碩士研究生的考生，將個人自述和簡歷(包括教育經(jīng)歷、工作經(jīng)歷、本科成績、英語四六級成績、獲獎、已發(fā)表文章等)發(fā)送至 xl2000bi@163.com。

　　歡迎廣大考生踴躍申請到秘曉林教授課題組攻讀碩士研究生!

掃描/長按二維碼關(guān)注獲取考研調(diào)劑

獲取2020考研調(diào)劑信息

獲取2020考研分?jǐn)?shù)線

獲取2套仿真內(nèi)部資料

獲取考研歷年真題答案

考研萬題庫下載丨微信搜索"萬題庫考研"

　　相關(guān)鏈接：

　　2020考研調(diào)劑信息 | 考生發(fā)布調(diào)劑信息 | 關(guān)注微信獲取調(diào)劑信息

　　2020考研復(fù)試分?jǐn)?shù)線專題 | 2020考研國家線 | 歷年復(fù)試分?jǐn)?shù)線 | 復(fù)試指導(dǎo)

　　2020考研成績查詢時(shí)間及入口專題 | 考研成績查詢微信提醒